De Valera or Valera is a surname of Spanish origin. It may refer to:
Cipriano de Valera (1531–1602), Spanish Protestant refugee Diego de Valera (1412–1488), Spanish writer Éamon de Valera (1882–1975), Irish statesman José Vincente de Valera (1822–1899), Spanish Army officer Máirin de Valéra, (1912–1984), Irish phycologist Rúaidhrí de Valera (1916–1978), Irish archaeologist Síle de Valera (born 1954), Irish Fianna Fáil politician Sinéad de Valera (1878–1975), wife of Éamon de Valera Vivion de Valera (1910–1982), Irish Fianna Fáil politician
See also Valera (disambiguation), which includes a list of people with the surname Varela