Quesne is a surname. Notable people with the surname include:
Charles Thomas Le Quesne (1885–1954), British Liberal Party politician and barrister Giffard Le Quesne Martel (1889–1958), British Army officer Martin Le Quesne (1917–2004), British diplomat, ambassador to Mali and Algeria and high commissioner to Nigeria Ferdinand Le Quesne (1863–1950), British army surgeon and recipient of the Victoria Cross Julien Quesne (born 1980), French golfer
See also Duquesne (disambiguation) Le Quesne, a commune in northern France Skylark DuQuesne, a science fiction novel by American writer E. E. Smith