Ghini is an Italian surname. Notable people with the surname include:
Alessandro Ghini (born 1961), Italian former rugby union player and a current coach Camilla Ghini (born 1994), Italian television presenter, radio personality and model Giovanni di Lapo Ghini (), Italian architect working in Florence Luca Ghini (1490–1556), Italian physician and botanist Massimo Ghini (born 1954), Italian actor Simone Ghini (1406/07–1491), Italian Renaissance sculptor from Florence
Also Palazzo Ghini, palace of the aristocratic Ghini family in Cesena, Italy