Jane was launched at Liverpool in 1805 as a slave ship in the triangular trade in enslaved people. An explosion, the result of a rebellion by her captives, destroyed her in 1806.

Jane first appeared in Lloyd's Register (LL) in 1805 with Magennis, master, Falkner & Co., owners, and trade Liverpool–Africa.LR (1805), Supple. pages "J", Seq.№99. Captain John Magginnis acquired a letter of marque on 22 July 1805. Captain John Maginnis sailed from Liverpool on 11 August 1805.Trans Atlantic Slave Trade Database – Jane voyage #81998.

While Jane, McGinnis, master, was at the Congo she blew up in 1806, reportedly as the result of a rebellion. The Trans Atlantic Slave Trade database reports that almost the entire crew and all the captives were killed. However, Lloyd's List (LL) reported that , a ship also gathering captives at the Congo, had rescued the master, crew, and 25 captives and delivered them to Dutch Guiana.LL 18 April 1806, №4045.Trans Atlantic Slave Trade Database – Byam voyage #80721. One source described the rebellion as partly successful in that it resulted in some captives regaining their freedom.

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