Mrs. Lowe may refer to:

Mrs. Lowe, a character from the 1990 film Awakenings Mrs. Lowe, a character from the 1973 film The Train Robbers Mrs. Lowe, a character from the 1960 film Comanche Station Mrs. Lowe, a character from the 2015 film Experimenter Mrs. Lowe, a character from the 1918 film The Eyes of Julia Deep

See also Lowe (surname)