Fabrizio Chiti (born in Florence, 7 July 1971) is an Italian biochemist noted for his work on Protein aggregation and amyloid.
Education Chiti is a graduate in Biological Sciences of the University of Florence (Italy). He attained a PhD degree (D.Phil) in Chemistry in 2000 at the University of Oxford in UK. He then worked as a postdoctoral researcher at the University of Florence, Italy, with Giampietro Ramponi as a supervisor (2000–2002) and at the University of Cambridge, UK, under the supervision of Chris Dobson (2002).
Research and career He was appointed as an Associate (2002) and then Full Professor (2010) at the University of Florence in Biochemistry. Chiti provided contributions in the field of misfolding and aggregation, particularly in the field of amyloid He rationalized how amino acid mutations induce protein aggregation and edited an equation to predict the effect of mutations on the aggregation of an unfolded protein, which led to a search by many investigators of algorithms with predictive power on essential aspects of protein aggregation. He also correlated the toxicities of abnormal protein oligomers with specific structural properties of them. His 2006 review with Chris Dobson on protein misfolding, amyloid formation and human disease, later updated as a new report, is a reference paper in the field of amyloid and received, as of October 2019, more than four thousands citations in scientific publications.
Awards and honors Election to EMBO Young Investigator program, European Molecular Biology Organization, 2005 Election to member of Academia Europaea, 2015 Jean-Francois LeFèvre Lecture, École supérieure de biotechnologie Strasbourg, 2003 Maria Teresa Messori Roncaglia ed Eugenio Mari Award, Accademia Nazionale dei Lincei, 2010
References
External links
Fabrizio Chiti's homepage at University of Florence Fabrizio Chiti's laboratory at University of Florence Department of Biomedical Experimental and Clinical Sciences at University of Florence