Setouchi may refer to:
Places Setouchi, Kagoshima, a town on Amami Islands, Japan Setouchi, Okayama, a city on Honshū, Japan Setouchi region, a region of Japan encompassing the Seto Inland Sea and adjacent coastal areas of Honshū, Shikoku, and Kyushu
People Jakucho Setouchi (1922–2021), Japanese Buddhist nun
Other Setouchi Volcanic Belt, a Miocene volcanic belt in southwestern Japan Setouchi Junior College, a private junior college in Mitoyo, Kagawa, Japan TV Setouchi, a television station in Okayama Prefecture and Kagawa Prefecture, Japan