Gafford is a surname. Notable people with the surname include:
Alice Taylor Gafford (1886–1981), American nurse, teacher, and artist Carl Gafford (born 1953), American comics artist Daniel Gafford (born 1998), American basketball player Monk Gafford (1920–1987), American football player Ray Gafford (1914–1990), American golfer Rico Gafford (born 1996), American football player Thomas Gafford (born 1983), American football player
See also Gafford, Texas, an unincorporated community in Hopkins County, Texas