Oyewole is a surname. Notable people with the surname include:
Abiodun Oyewole (born 1948), American musician Adessoye Oyewole (born 1982), Russian footballer Olusola Bandele Oyewole (born 1955), Nigerian professor Saundra Herndon Oyewole (born 1943), American microbiologist Ayodeji John Oyewole (born 2004), Nigerian Petroleum Engineer