Bophumpa Creek is a stream in Holmes County in the U.S. state of Mississippi. It is a tributary to Fannegusha Creek.Lexington North, MS, 7.5 Minute Topographic Quadrangle, USGS, 1982

The stream headwaters arise at at an elevation of approximately 420 feet.Bowling Green, MS, 7.5 Minute Topographic Quadrangle, USGS, 1964 (1982 rev.) The stream flows generally westward for approximately six miles through a rural area passing under Mississippi Highway 17 one mile north of the community of Lebanon to its confluence with Fannegusha Creek at at elevation of 197 feet.

Bophumpa Creek is a name derived from the Choctaw language purported to mean either "rain creek" or "pawpaw creek". A variant name is "Sweet Water Creek".

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