DeGroff is a surname. Notable people with the surname include:
Alzina Orndorff DeGroff, American businesswoman and civic activist Dale DeGroff (born 1948), American bartender and author Edward DeGroff (1860–1910), American merchant and photographer John DeGroff, American Christian musician John W. DeGroff (1843–1895), American politician Rube DeGroff (1879–1955), American baseball player