Destroy All Humans! is an open-world action-adventure video game series. It may also refer to:
Games in the video game series Destroy All Humans! (2005 video game), the first game in the series Destroy All Humans! 2 (2006), the second game in the series Destroy All Humans! Big Willy Unleashed (2008) Destroy All Humans! Path of the Furon (2008) Destroy All Humans! (2020 video game), a remake of the first game Destroy All Humans! 2: Reprobed (2022), a remake of the second game
Other uses Destroy All Humans. They Can't Be Regenerated. (2018–present), a manga series Destroy All Humans, a 2020 studio album by Hittman