DeShong, also spelt Deshong, is a surname. Notable people with the surname include:
Alfred O. Deshong (1837–1913), American industrialist, philanthropist, and art collector Andrea DeShong (born 1962), American boxer Jimmie DeShong (1909–1993), American professional baseball pitcher John O. Deshong (1807–1881), American businessman and banker Michelle Deshong, Aboriginal Australian political scientist and advocate for gender equality Peter Deshong (1781–1827), American businessman and banker
See also Deshong Art Museum, former art museum in Chester, Pennsylvania Deshong Park, a park in Chester, Pennsylvania.