The Natanebi () is a river in western Georgia, located in the region of Guria. It originates on the northern slope of the Meskheti Range, at an altitude of 2,548 m above sea level. It flows into the Black Sea near Shekvetili. It is long, and has a drainage basin of .Statistical Yearbook of Georgia: 2020, National Statistics Office of Georgia, Tbilisi, 2020, p. 12.Georgian Soviet Encyclopedia Vol. 7, p. 327, 1984.
The Natanebi corresponds to the ancient River Isis, described by Greek historian Arrian of Nicomedia in his Periplus of the Euxine Sea.Arrian, William Falconer, and Thomas Falconer. Arrian's Voyage Round the Euxine Sea Translated; And Accompanied with a Geographical Dissertation, and Maps. Oxford: J. Cook, 1805.
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