Pernice () is an Italian surname meaning "partridge".
Notable people with this surname include:
Erich Pernice (1864–1945), German classical archaeologist Gino Pernice (1927–1997), Italian stage, television and film actor Giovanni Pernice (born 1990), Italian dancer and choreographer Hugo Karl Anton Pernice (1829–1901), German gynecologist Joe Pernice (born 1967), American musician Tom Pernice Jr. (born 1959), American golfer