De Francesco (or de Francesco) is an Italian surname. Notable people with this surname include:
Alberto De Francesco (born 1994), Italian football player Devlin DeFrancesco (born 2000), Canadian-Italian auto racing driver Francesco De Francesco (born 1977), Italian football striker Grete De Francesco (1893–1945), German-speaking writer Joey DeFrancesco (1971–2022), American jazz organist, trumpeter, saxophonist, and occasional singer John DeFrancesco (1940–2024), American jazz organist and vocalist Johnny DeFrancesco (born 1965), merican blues guitarist Lucas de Francesco (born 1981), Italian football striker Matteuccia de Francesco (died 1428), an alleged Italian witch and nun Roberto De Francesco (born 1964), Italian actor Sebastian DeFrancesco (1953–2023), American paralympic athlete and table tennis player Tony DeFrancesco (born 1963), American baseball coach
See also Francesco Di Francesco