Hypius or Hypios (), also Hyppius or Hyppios (Ὕππιος), was a river of ancient Bithynia, not far westward from the Sangarius River. The river itself is very small; but at its mouth it is so broad that the greater part of the fleet of Mithridates was enabled to take up its winter quarters in it.Apollon. 2.795; Periplus of Pseudo-Scylax, p. 34; Marcian of Heraclea, Menippi periplus maris interni, p. 70; Memnon, ap. Phot. Cod. 44. According to the Periplus of Pseudo-Scylax, this river formed the boundary between the territories of the Bithyni and the Mariandyni.

It is identified with the modern Büyük Melen Su in Asiatic Turkey.

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