Melillo is a surname. Notable people with this surname include:

Alberto Melillo (1866–1915), Italian painter Angela Melillo (born 1967), Italian actress, showgirl, model, singer, and television hostess David Andrew Melillo (born 1988), the American former lead guitarist for the rock band Anarbor Eric Melillo (born 1998), Canadian politician Ezequiel Melillo (footballer, born 1990), Argentine professional football midfielder for Almirante Brown Ezequiel Melillo (footballer, born 1993), Argentine professional football midfielder for Vibonese Joseph V. Melillo, the executive producer at the Brooklyn Academy of Music (BAM) from 1999 to 2018 Michael Melillo (born 1982), former American professional baseball player Oscar Donald "Ski" Melillo (1899–1963), American second baseman and coach

See also Milillo