D'Orsi is a surname of Italian origin. Notable people with the surname include:
Achille D'Orsi (1845–1929), Italian sculptor from Naples Angelo d'Orsi (b. 1947), Italian historian (1930–2010), Italian philosopher (b. 1958), Italian politician, president of the Province of Agrigento Juan Zanassi, born Juan Francisco Zanassi D'Orsi (1947–2022), Argentine rower and journalist (1888–1977), Italian archaeologist Lucy D'Orsi (born 1969), British police officer (1897-1964), Brazilian-American animator Umberto D'Orsi (1929–1976), Italian character actor and comedian
Fictional characters Enrico D'Orsi, played by Jean-Louis Trintignant in the Italian film La terrazza (1980) Commander D'Orsi, played by Omar Sy in the French film The Wolf's Call (2019)
See also Orsi D'arcy (name) Jean-Baptiste-François Gigot d'Orcy (1737–1793), French entomologist and mineralogist