Di Costanzo is an Italian surname. Notable people with the surname include:
Angelo di Costanzo (c. 1507 – 1591), Italian historian and poet Greg "Storm" DiCostanzo, a member of the duo Paul and Storm Luigi Di Costanzo (born 1982), Italian water polo player Marco Di Costanzo (born 1992), Italian rower Mario Alberto di Costanzo Armenta (born 1962), Mexican economist and politician from the Labor Party Cuono "Nello" Di Costanzo (born 1961), Italian football manager and former player Richard A. DiCostanzo (1908–?), New York state senator 1943–1946
See also Costanzo