Sisti is a surname. Notable people with this surname include:
Giancarlo De Sisti (born 1943), retired Italian footballer and football manager and midfielder Anthony J. (Tony) Sisti (1901–1983), American artist, art instructor and patron of the arts Michael Sisti, American women's ice hockey current head coach at Mercyhurst University. Michelan Sisti (born 1949), Puerto Rican-American actor, director, puppeteer, and musician Romeo Sisti, Italian rower Sebastian Daniel "Sibby" Sisti (1920–2006), American Major League Baseball utility player Vittorio De Sisti (1940–2006), Libyan-born Italian director and screenwriter