Spina is an Etruscan port city established by the end of the 6th century BCE on the Adriatic, Italy.

Spina may also refer to:

Spina (surname), a surname

Places Italy Spina di Gualdo, a mountain of Marche Monti la Spina – Zaccana, a mountain of Basilicata Monte Spina, a mountain of Lombardy Spina Nuova, a frazione of the comune of Campello sul Clitunno in the Province of Perugia, Umbria, central Italy

Other places Spina, Minnesota, abandoned townsite in Great Scott Township, Saint Louis County, Minnesota, U.S.

Anatomy Spina helicis, a small projection of cartilage at the front part of the auricula Spina iliaca posterior inferior, at the posterior and inferior surface of the iliac bone Spina iliaca posterior superior, the posterior border of the ala of sacrum Spina ischiadica, from the posterior border of the body of the Ischium Spina nasalis anterior maxillae, bony projection in the skull in the order of cephalometric landmark Spina nasalis posterior ossis palatini, attachment of the musculus uvulae Spina suprameatica, at the inner end of the external acoustic meatus, in the tympanic membrane Spina ventosa, a skeletal manifestation of tuberculosis Spina vestibuli, a triangular thickening near the coronary sinus

Zoology Cingulina spina, a species of sea snail, a marine gastropod mollusk in the family Pyramidellidae Damochlora spina, a species of air-breathing land snails, terrestrial pulmonate gastropod mollusks Pollex spina, a moth of the family Erebidae

Other uses Santa Maria della Spina, a small church in Pisa, Italy Assunta Spina (1915 film), a 1915 Italian silent film Parco Spina Verde di Como, regional natural park in Lombardy, Italy Peggy Spina Tap Company, an American tap dance company Ziziphus spina-christi or Christ's thorn jujube, an evergreen plant native to northern and tropical Africa Spina of a hippodrome, a low wall running most of the length of a hippodrome and dividing the course