Prions are misfolded proteins which characterize several fatal neurodegenerative diseases in humans and many other animals.

Prion may also refer to:

Science Fungal prion, a prion that infects fungal hosts Prion protein, the human gene encoding for the major prion protein PrP (for prion protein) Prion diseases, a group of progressive and invariably fatal symptoms affecting the brain (encephalopathies) and nervous system of many animals Prion pruritus, an intense itching during the prodromal period of the Creutzfeldt–Jakob disease Prion pseudoknot, a predicted RNA pseudoknot structure found in prion protein mRNA Prion (journal), a journal on protein folding, misfolding, assembly disorders and structural inheritance

Other uses Prion (bird) List of prions Prion Humour Classics, a series of novels published by Prion Books in the UK Prion Island, located in the Bay of Isles, South Georgia National Prion Clinic (UK), a British specialist prion disease clinic Eran Prion (born 1974), Israeli musician and music producer Prion, Denbighshire, village in Wales