Casalini is an Italian surname. Notable people with the surname include:
Corrado Casalini, former Italian professional football player Emilio Casalini (born 1941), Italian racing cyclist Franco Casalini (1952–2022), Italian basketball coach Giancarlo Casalini (1934–2009), Italian rower Lucia Casalini Torelli (1677–1762), Italian painter, active in Bologna Oreste Casalini (1962–2020), Italian painter and sculptor