Pierina is an Italian and Spanish feminine given name. Notable people with the name include:
Pierina Borsani (1909–1960), Italian female basketball player and athlete Pierina Carcelén, Peruvian actress, model and dancer Pierina Dealessi (1894–1983), Italian-born Argentine actress Pierina Gilli (1911–1991), Italian Roman Catholic visionary Pierina Legnani (1868–1930), Italian ballerina Pierina Montenegro (born 1986), Uruguayan footballer Pierina Morosini (1931–1957), Italian Roman Catholic from Bergamo who was killed after a man tried to rape her
See also Maria Pierina (1890–1945), Roman Catholic religious Sister