Mazzei is an Italian surname. Notable people with the surname include:
Andrew Mazzei (1887–1975), British art director Barbara Mazzei, Italian archaeologist Francesco Mazzei (born 1973), Italian chef Frank Mazzei (1912–1977), American politician from Pennsylvania Isa Mazzei, American screenwriter, author, and film producer Júlio Mazzei (1930–2009), Brazilian soccer coach Mike Mazzei (born 1965), American politician from Oklahoma Philip Mazzei (1730–1816), Italian physician Santo Mazzei (born 1953), Sicilian mafioso
See also Massei, surname Mazzei v. Commissioner, 1974 lawsuit Mazzi, surname SS Filipp Mazzei, ship