Fagnani is a noble Italian surname derived from various places called Fagnano. Notable people with the surname include:
Antonietta Fagnani Arese (1778–1847), Italian noblewoman and woman of letters Francesca Fagnani (born 1976) is an Italian journalist, writer and television presenter Maria Seymour-Conway (; 1771–1856), British noblewoman Nina Fagnani (1856–1928), American painter of portrait miniatures Prospero Fagnani (1588–1678), Italian canon lawyer