Ampuero is a surname. Notable people with the surname include:
Álvaro Ampuero (born 1992), Peruvian footballer Branco Ampuero (born 1993), Chilean footballer Evelyn Ampuero (born 1987), Peruvian volleyball player Jorge Ampuero (born 1987), Chilean footballer José Joaquín Ampuero y del Río (1872–1932), Spanish politician and businessman José María Ampuero Jáuregui (1837–1917), Spanish politician Juan Carlos Sánchez Ampuero (born 1985), Bolivian footballer Ramón Miranda Ampuero (born 1926), Peruvian general and minister Roberto Ampuero (born 1953), Chilean author, columnist and minister