The Frederick Hotel is a historic building in Loup City, Nebraska. It was built in 1913 for Viola Rosseter Odendahl, the daughter of hotelier Cyrus Rosseter and the widow of druggist Charles Odendahl. With In 1939, the hotel was acquired by Odendahl's sons and has undergone a number of ownership changes since then. It has been in continuous operation since it was opened in 1913. The building was listed on the National Register of Historic Places on October 16, 2002. It is now known as The Historic Frederick Hotel.
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