TLE may stand for:
Arts and entertainment The Living End, an Australian band formed in 1994 Star Trek: The Lost Era, a novel series in the Star Trek franchise Lost Experience, a game based on the Lost television series
Medicine Temporal lobe epilepsy, the most common form of focal seizure, originating in the temporal lobe of the brain
Science and technology Kimber Custom TLE II, a model of the Kimber Custom handgun Temporal light effects, wanted or unwanted effects caused by light modulations Total lunar eclipse, an astronomical event Transient luminous event, or upper-atmospheric lightning, a weather phenomenon Two-line element set, a format for distributing orbital element data
Other uses Technology and Livelihood Education, part of an educational curriculum in the Philippines The London Economic, a left-wing digital newspaper based in the UK