The men's 160 + 320 + 480 + 640 medley relay event at the 1966 European Indoor Games was held on 27 March in Dortmund. The first athlete ran one lap of the 160-metre track, the second two, the third three and the anchor four, which gave in total 10 laps or 1600 metres.

Results RankNationCompetitorsTimeNotes Leonhard HändlWerner KrönkeRolf KrüsmannJürgen Schröter 3:22.0 Bruno BianchiIto GianiSergio OttolinaSergio Bello 3:22.2 Werner OijzersWilly VandewyngaerdenGeorges WijnantsAlbert van Hoorn 3:27.2

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