Twelfth Avenue is a short portion of the West Side Highway in Manhattan.
Twelfth Avenue or 12 Av could also refer to:
13th Avenue (Borough Park), the commercial center of Borough Park, Brooklyn 12th Avenue South Bridge, a permanent steel bridges in Seattle. Clinton Street/Southeast 12th Avenue station, a train station in Portland, Oregon. Washington/Southeast 12th Avenue station, a train station in Hillsboro, Oregon. Judah and 12th Avenue station, a train station in San Francisco, California. 12 Av, the twelfth day of Av, the fifth month of the Hebrew calendar