Speak up or Speak Up may refer to:
Technology Speakup, the screen reader
Entertainment Speak Up! It's So Dark, a Swedish drama film "Speak Up" (Pop Etc song), a song by Pop Etc "Speak Up, Francine!", an episode of the TV series Arthur Speak Up!, graphic novel
Other uses Speak Up, a campaign and national hotline from The Center to Prevent Youth Violence Speak Up, a feminist initiative encouraging women to speak out about harassment, founded by Gehad Hamdy