Spinella is an Italian surname. Notable people with the surname include:
Ezequiel Spinella (born 1999), Argentine footballer Ralph Spinella (1923–2021), American fencer Stephen Spinella (born 1956), American actor
Other uses Spinella (brachiopod), an extinct genus in order Palaeocopida Spinella, a taxonomic synonym for a genus of plants, Riccardia
Spinella