Gayoso is a Spanish surname and may refer to:
People Notable people with this surname include: Ander Gayoso (born 1993), Spanish footballer Javier Gayoso (born 1997), Filipino footballer Manuel Gayoso (born 1944), Spanish runner Manuel Gayoso de Lemos (1747–1799), Spanish military officer Roberto Trashorras Gayoso (born 1981), Spanish footballer
Places Gayoso, Missouri, United States