Guse is a surname. Notable people with the surname include:
Bernd Guse (born 1941), West German sprint canoer Bruno Guse (born 1939), German boxer Kerry-Anne Guse (born 1972), Australian tennis player Udo Guse (born 1967), German weightlifter Captain William David Guse CD, BSc, CCPA, DMT, (born 1971), RCMS Physician Assistant, United Nations & NATO Veteran LTC Steven D. Guse (born 1944), USA Airforce B52 pilot
See also Gose (surname)