Sedley is a surname, and may refer to:
Amelia Sedley, fictional character from the novel Vanity Fair by William Makepeace Thackeray Catherine Sedley, Countess of Dorchester (1657–1717), mistress of King James II Sir Charles Sedley, 2nd Baronet (1721–1778), British politician Sir Charles Sedley, 5th Baronet (1639–1701), English wit, dramatist and politician, and Speaker of the House of Commons David Sedley (born 1947), the seventh Laurence Professor of Ancient Philosophy at Cambridge University Kate Sedley, the pen-name of Brenda Margaret Lilian Honeyman Clarke (1926–2022), English historical novelist Stephen Sedley, (born 1939), (The Rt. Hon. Lord Justice Sedley), a judge of the Court of Appeal of England and Wales William Sedley, High Sheriff of Kent in 1547