Prather is a surname. Notable people with the surname include:
Casey Prather (born 1991), American basketball player in the Israeli Basketball Premier League Chad Prather, American motivational speaker Colt Prather (born 1975), American country music singer-songwriter Dale Prather (1910–1973), American football player Guy Prather (1958–2016), American National Football League linebacker (1981–1985) H. Lee Prather (1886–1964), American head football and basketball coach at Northwestern State University Hugh Prather (1938–2010), American self-help writer Joan Prather (born 1950), American actress Joe Prather (born 1939), American politician Kaden Prather (born 2002), American football player Lenore L. Prather (1931-2020), American judge Maurice Prather (1926–2001), American cinematographer Richard S. Prather (1921–2007), American mystery novelist Rollin Prather (1925–1996), Canadian Football League player Victor Prather (1926–1961), American flight surgeon who died testing the "Project RAM" space suit