USS Prometheus may refer to the follow ships of the United States Navy:
, a brig in the United States Navy from 1814 to 1818 , a repair ship that served during World War I and World War II
USS Prometheus may refer to the follow ships of the Startrek franchise: USS Prometheus, a fictional spacecraft in the episode "Message in a Bottle" of Star Trek: Voyager USS Prometheus, a fictional starship in the episode "Second Sight" of Star Trek: Deep Space Nine