Cacace () is a Southern Italian surname. It originated from a Neapolitan nickname meaning "wicked", from the Medieval Greek word kakakēs. Notable people with the surname include:
Alejandro Cacace (born 1985), Argentine politician Anthony Cacace (born 1989), Irish boxer Ezequiel Cacace (born 1984), Argentine soccer player Flavia Cacace (born 1980), Italian-born British dancer Fulvio Cacace (?–2003), Italian chemist Joel Cacace (born 1941), New York City mobster Liberato Cacace (born 2000), New Zealand soccer player Susan Cacace (New York) (born 1964), American politician (born 1979), Italian model
See also Cacace Chapel, a chapel in the church of San Lorenzo Maggiore, Naples Kachalsky v. Cacace, 2012 lawsuit
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