The 1949–50 Macedonian Republic League was the sixth since its establishment. Rabotnik Bitola won their first championship title.
Participating teams
Club City Bregalnica Shtip Crvena Dzvezda Veles Kozhuf Gevgelija Ohrid Ohrid Pitu Guli Krushevo Pobeda Prilep Rabotnik Bitola Shar Tetovo Sloga Skopje Student Skopje Tekstilec Skopje Tikvesh Kavadarci
Final table
References Karovski, Ilija (1996) FK Tikvesh 1930–1995 p. 32, 33, 34
External links SportSport.ba Football Federation of Macedonia