In organic chemistry, an aminomethyl group is a monovalent functional group with formula . It can be described as a methyl group substituted by an amino group . Commonly aminomethylations are the result of a Mannich reaction.
Related compounds Usually aminomethyl groups feature tertiary amines. Often they are obtained by alkylation with Eschenmoser's salt, a source of [CH2=N(CH3)2]+..
A cobalt(III) complex of aminomethyl is known in the form [Co(bipyridine)2(CH2NH2)](ClO4)2.
Aminomethyl is the first member of a series of 1-aminoalkyl groups of the form .Erwin Von Angerer, Norbert Knebel, Mario Kager, and Bernhard Ganss (1990): "1-(aminoalkyl)-2-phenylindoles as novel pure estrogen antagonists". Journal of Medicinal Chemistry, volume 33, issue 9, pages 2635–2640.
Aminomethyl is used in the standard (IUPAC) names of some compounds,Ursula Bünzli-Trepp (2007): Systematic Nomenclature of Organic, Organometallic and Coordination Chemistry: Chemical-Abstracts Guidelines with IUPAC Recommendations and Many Trivial Names. EPFL Press, 636 pages. such as 4-(aminomethyl) benzoic acid.
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