Spilker is a surname. Notable people with the surname include:
Annemarie Spilker (born 1980), Dutch photographer Hendrik Storstein Spilker (born 1965), Norwegian sociologist and media studies scholar James Spilker (1933–2019), American engineer and a Consulting Professor in the Aeronautics and Astronautics Department at Stanford University Linda Spilker (born 1955), American planetary scientist Marc Spilker (born 1964), American financial executive and investor