Pillsbury, also spelled Pilsbury, is a surname. Notable people with the name include:

People Agnes Hope Pillsbury (1876–1937), American pianist, music educator Albert E. Pillsbury (1849–1930), American lawyer and politician Arthur Clarence Pillsbury (1870–1946), American photographer Charles Alfred Pillsbury (1842–1899), founder of C.A. Pillsbury and Company (later Pillsbury Company) Edward Pilsbury (1824–1882), 38th mayor of New Orleans George A. Pillsbury (1816–1898), businessman and miller associated with the formation of the Pillsbury Company George S. Pillsbury (1925–2012) American businessman and politician Gilbert Pillsbury (1813–1893), Reconstruction mayor of Charleston, South Carolina Harry Nelson Pillsbury (1872–1906), American chess player John E. Pillsbury (1846–1919), United States Navy rear admiral John S. Pillsbury (1827–1901), Governor of Minnesota Mary Pillsbury Weston (1817-1895), American painter Matthew Pillsbury (born 1973), American photographer Michael Pillsbury (born 1945), American director of the Center on Chinese Strategy and author Parker Pillsbury (1809–1898), American abolitionist Philip W. Pillsbury (1903–1984), American chairman emeritus of the Pillsbury Company and a grandson of the cofounder Sam Pillsbury, American film director and producer Timothy Pilsbury (1789–1858), American politician Walter Bowers Pillsbury (1872–1960), American psychologist Wilmot Pilsbury (1840–1908), English watercolourist and art teacher

Fictional characters Emma Pillsbury, Glee character Rose Pillsbury, Glee character Rusty Pillsbury, Glee character