Tamagnini is a surname. Notable people with the surname include:
Alberto Tamagnini (2002–), Sammarinese alpine ski racer Fernando Tamagnini de Abreu e Silva (1856–1924), Portuguese general and commander of the Portuguese Expeditionary Corps in World War I Filippo Tamagnini (1972–), Sammarinese politician João Tamagnini Barbosa (1883–1948), Portuguese military officer and politician Lucia Tamagnini (1963–) Sammarinese politician Nené (1949–), real name Tamagnini Manuel Gomes Batista, Portuguese footballer Roberto Tamagnini (1942–), Sammarinese sports shooter Torquato Tamagnini (1886–1965), Italian sculptor and medallist Vittorio Tamagnini (1910–1981), Italian bantamweight boxer