Spadafora is a surname. Notable people with the surname include:
David Spadafora, American historian Domenico Spadafora (1450–1521), Italian Roman Catholic priest Hugo Spadafora (1940–1985), Italian-Panamanian physician and guerrilla fighter Paul Spadafora (born 1975), American boxer Ronald Spadafora (1954–2018), American firefighter
See also Spadafora family