Enzo Adrián Lettieri (born 19 July 1998) is an Argentine professional footballer who plays as a defender for Chilean club Deportes Temuco.

Career After a nine-year stint in the youth of Independiente de Monte, Lettieri joined Nueva Chicago's academy in 2015. A 2–0 defeat at the Estadio La Ciudadela to San Martín on 28 July 2017 in Primera B Nacional saw Lettieri make his professional debut, with the defender starting and finishing the fixture under manager Facundo Argüello. At the end of 2022, his contract with Nueva Chicago ended and he joined Club Atletico Chacarita Juniors until the end of 2023.

In 2025, Lettieri moved to Chile and joined Deportes Temuco.

Career statistics . + Appearances and goals by club, season and competitionClubSeasonLeagueCupContinentalOtherTotalDivisionAppsGoalsAppsGoalsAppsGoalsAppsGoalsAppsGoalsNueva Chicago2016–17Primera B Nacional1000—00102017–180010—00102018–190000—00002019-2010000000102020-21500000005020212500000002502022211000000211Chacarita Juniors2023Primera Nacional110100000120Career total64120—00661

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