Milazzo is a surname. Notable people with the surname include:
Gaspar Milazzo (1887–1930), Italian-born American mobster Ivo Milazzo (born 1947), Italian comic book artist Jane Margaret Triche Milazzo (born 1957), American judge Richard Milazzo, American art critic, curator, publisher, independent scholar and poet Silvio Milazzo (1903–1982), Italian politician Vincenzo Milazzo (born 1956), Italian painter