Niccolini is a surname. Notable people with the surname include:
Antonio Niccolini (abbot) (1701–1769), Italian abbot, jurist and scholar Antonio Niccolini (architect) (1772–1850), Italian architect and engraver Dianora Niccolini (born 1936), Italian fine art photographer Francesco Niccolini (1639–1692), Italian archbishop and diplomat Giovanni Battista Niccolini (1782–1861), Italian poet and playwright Ippolito Niccolini (1848–1919), Italian businessman and politician Julian Niccolini, American restaurateur