Rupen may refer to:
People Rupen of Montfort (died 1313), Cypriot nobleman Rupen Sevag, real name Ruben Çilingiryan (1886–1915), Ottoman Armenian poet, prose writer and doctor, killed by Turkish authorities during the Armenian Genocide Rupen Zartarian (1874–1915), Ottoman Armenian writer, educator, and political activist, killed by Turkish authorities during the Armenian Genocide
Places Rupen River, Gujarat, India Rupen River (Gir), Gujarat, India
See also Reuben, a given name Roupen, a given name